Supersets and giant sets work well for inducing metabolic stress, especially those that stress the muscle at different lengths.
Here's a skull crusher variation where I lower the bar to my nose for 10 reps, then to my forehead for 10 reps, then behind the head for 10 reps. Try it!
A competitive powerlifter recently contacted me to correct his woefully pathetic bench press. After a few tests and some obvious visual clues, I realized that his triceps were holding him back from pressing up big numbers.