The Hammer Strength unilateral supinated-grip pulldown is one of my favorite machines. It's nearly impossible to duplicate with free weights what this machine can do.
Several training methods work great on this machine, like maximum tension alternating pulls (hold one side isometrically in the contracted position at the bottom while the other side is moving). It also works great with bands for added accommodating resistance.
Tim's "Ah-Ha" moments have to do with the superiority of supersets over combination exercises, working abs first, the proper way to gain weight, debunking the stability ball myth, and a nifty little trick to make sure you're squatting low enough.