Calves are the hardest muscle group to transform. Historically, humans had to walk for hours each day. The ankle joint is primarily solicited during that action. If all the effort of propelling your body was provided by a muscular effort of the calves, they'd tire out too fast.
That's why the Achilles tendon is so stiff and strong: it's the stretch-reflex of the Achilles that does a large part of the work at the ankle joint. The same thing that makes locomotion efficient also makes it hard to make the calves grow. The Achilles has a very strong and highly reactive stretch-reflex. When you do regular reps on calf exercises, it's that reflex that does most of the work. As a result, the muscles themselves don't contribute that much, thus they aren't stimulated optimally.
Furthermore, the range of motion on calf exercises is very short. If you do 8-12 reps, the time in which the muscles are under tension is too short to stimulate maximal hypertrophy. Lastly, the fascia surrounding the calves is the tightest of all the body. If it's too tight it can actually limit muscle growth.
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