If you don't feel a muscle working during an exercise, you won't stimulate that muscle enough to grow at a maximal rate. Even when training for strength – using heavy weights and low reps – you should feel the proper muscles doing the work. You won't get a big pump in these muscles from strength work, but the target muscles should feel harder after a set.
If you lack the motor skill to optimally activate a specific muscle during a big lift, use isolation work for that muscle to learn to recruit and flex it maximally. When you're good at recruiting that muscle, it'll become more involved in the big lifts. Doing isolation work for a muscle you don't otherwise feel properly is an investment in future gains.
This is the progression I prescribe for someone who doesn't feel a specific muscle working during a big lift. I call it the "isolate to integrate" approach. Each step should last 2-4 workouts.
Using this approach allowed me to start using my pecs more in the bench press. I used to be all-shoulders in the bench. Despite bench-pressing in the 400-plus range, I had zero pectoral development. The isolate-to-integrate method helped me to bring in the pecs for bigger lifts and better development.
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