If your goal is hypertrophy, try this loading method. This is a very effective (and painful) method for getting in a lot of rep work. Works great with just about any exercise.
Pick a weight that you try to do for 50 total reps over the course of three working sets. For most people, choosing a weight that allows you to get 18 to 22 reps on the first set is about right. Once you're able to get a total of 50 reps over 3 sets, add weight.
I used this on incline presses and found that when my 3-50 sets went up, so did my other pressing. For example, initially I picked 225 as my 50-rep weight. Generally, my sets fell into these kinds of ranges:
I stayed with 225 until I was able to get the 50 total. After that I started going after 50 total reps with a heavier weight. Give it a shot!
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